ExplorEnz: EC 2.6.1.63

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2.6.1.63

Accepted name:

kynurenine—glyoxylate transaminase

Reaction:

(1) L-kynurenine + glyoxylate = kynurenate + glycine + H₂O (overall reaction)
(1a) L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
(1b) 4-(2-aminophenyl)-2,4-dioxobutanoate = kynurenate + H₂O (spontaneous)
(2) 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H₂O (overall reaction)
(2a) 3-hydroxy-L-kynurenine + glyoxylate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine
(2b) 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate = xanthurenate + H₂O (spontaneous)

For diagram of EC 2.6.1, click here

Other name(s):

kynurenine-glyoxylate aminotransferase

Systematic name:

L-kynurenine:glyoxylate aminotransferase (cyclizing)

Comments:

This enzyme, characterized from animals, belongs to a family of aminotransferases some members of which can use other amino acceptors (cf. EC 2.6.1.7, kynurenine—oxoglutarate transaminase). The products, 4-(2-aminophenyl)-2,4-dioxobutanoate and 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate, are converted to kynurenate and xanthurenate, respectively, by spontaneous reactions.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 74506-33-5

References:

1.	Harada, I., Noguchi, T. and Kido, R. Purification and characterization of aromatic-amino-acid-glyoxylate aminotransferase from monkey and rat liver. Hoppe-Seylers Z. Physiol. Chem. 359 (1978) 481–488. [DOI] [PMID: 25837]
2.	Harada, I. [Glucagen inducible kynurenine aminotransferase.] Wakayama Igaku 31 (1980) 61–68. (in Japanese)
3.	Han, Q., Fang, J. and Li, J. 3-Hydroxykynurenine transaminase identity with alanine glyoxylate transaminase. A probable detoxification protein in Aedes aegypti. J. Biol. Chem. 277 (2002) 15781–15787. [DOI] [PMID: 11880382]
4.	Rossi, F., Lombardo, F., Paglino, A., Cassani, C., Miglio, G., Arca, B. and Rizzi, M. Identification and biochemical characterization of the Anopheles gambiae 3-hydroxykynurenine transaminase. FEBS J. 272 (2005) 5653–5662. [DOI] [PMID: 16262702]

[EC 2.6.1.63 created 1983]