The Enzyme Database

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EC 2.6.1.40     
Accepted name: (R)-3-amino-2-methylpropionate—pyruvate transaminase
Reaction: (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
For diagram of reaction, click here
Other name(s): D-3-aminoisobutyrate—pyruvate transaminase; β-aminoisobutyrate-pyruvate aminotransferase; D-3-aminoisobutyrate-pyruvate aminotransferase; D-3-aminoisobutyrate-pyruvate transaminase; (R)-3-amino-2-methylpropionate transaminase; D-β-aminoisobutyrate:pyruvate aminotransferase
Systematic name: (R)-3-amino-2-methylpropanoate:pyruvate aminotransferase
Comments: The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.22, (S)-3-amino-2-methylpropionate transaminase, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37279-00-8
References:
1.  Kakimoto, Y., Taniguchi, K. and Sano, I. D-β-Aminoisobutyrate:pyruvate aminotransferase in mammalian liver and excretion of β-aminoisobutyrate by man. J. Biol. Chem. 244 (1969) 335–340. [PMID: 5773299]
2.  Tamaki, N., Sakata, S.F. and Matsuda, K. Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver. Methods Enzymol. 324 (2000) 376–389. [PMID: 10989446]
[EC 2.6.1.40 created 1972 (EC 2.6.1.61 created 1982, incorporated 2004) modified 2004]
 
 


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