EC |
2.6.1.2 |
Accepted name: |
alanine transaminase |
Reaction: |
L-alanine + 2-oxoglutarate = pyruvate + L-glutamate |
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For diagram of reaction, click here and for mechanism, click here |
Other name(s): |
glutamic-pyruvic transaminase; glutamic-alanine transaminase; GPT (ambiguous); alanine aminotransferase; alanine-α-ketoglutarate aminotransferase; alanine-pyruvate aminotransferase; ALT; glutamic acid-pyruvic acid transaminase; glutamic-pyruvic aminotransferase; L-alanine aminotransferase; L-alanine transaminase; L-alanine-α-ketoglutarate aminotransferase; pyruvate transaminase; pyruvate-alanine aminotransferase; pyruvate-glutamate transaminase |
Systematic name: |
L-alanine:2-oxoglutarate aminotransferase |
Comments: |
A pyridoxal-phosphate protein. 2-Aminobutanoate can act slowly instead of alanine. |
Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9000-86-6 |
References: |
1. |
Dumitru, I.F., Iordachescu, D. and Niculescu, S. Chromatographic purification, crystallization and study of vegetable L-alanine: 2-oxoglutarate-aminotransferase properties. Experientia 26 (1970) 837–838. [PMID: 5452003] |
2. |
Dumitru, I.F., Iordachescu, D. and Niculescu, S. L-Alanine: 2-oxoglutarate-aminotransferase chromatographic purification and crystallization of the enzyme from seeds of Glycine hispida var Cheepeura. Rev. Roum. Biochim. 7 (1970) 31–44. |
3. |
Green, D.E., Leloir, L.F. and Nocito, W. Transaminases. J. Biol. Chem. 161 (1945) 559–582. [PMID: 21006939] |
4. |
Iordachescu, D., Dumitru, I.F. and Corniciuc, M.-T. Comparative biochemical studies concerning L-alanine: 2-oxoglutarate-aminotransferase from the liver and the bile of swines. Rev. Roum. Biochim. 20 (1983) 173–179. |
5. |
Wilson, D.G., King, K.W. and Burris, R.H. Transaminase reactions in plants. J. Biol. Chem. 208 (1954) 863–874. [PMID: 13174595] |
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[EC 2.6.1.2 created 1961] |
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