The Enzyme Database

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EC 2.5.1.94     
Accepted name: adenosyl-chloride synthase
Reaction: S-adenosyl-L-methionine + chloride = 5-deoxy-5-chloroadenosine + L-methionine
Glossary: 5-deoxy-5-chloroadenosine = 5′-chloro-5′-deoxyadenosine
Other name(s): chlorinase; 5′-chloro-5′-deoxyadenosine synthase
Systematic name: S-adenosyl-L-methionine:chloride adenosyltransferase
Comments: This enzyme, isolated from the marine bacterium Salinispora tropica, catalyses an early step in the pathway leading to biosynthesis of the proteosome inhibitor salinosporamide A. The enzyme is very similar to EC 2.5.1.63, adenosyl-fluoride synthase, but does not accept fluoride.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Eustaquio, A.S., Pojer, F., Noel, J.P. and Moore, B.S. Discovery and characterization of a marine bacterial SAM-dependent chlorinase. Nat. Chem. Biol. 4 (2008) 69–74. [PMID: 18059261]
[EC 2.5.1.94 created 2011]
 
 


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