The Enzyme Database

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EC 2.5.1.70     
Accepted name: naringenin 8-dimethylallyltransferase
Reaction: dimethylallyl diphosphate + (-)-(2S)-naringenin = diphosphate + sophoraflavanone B
For diagram of sophoraflavanone-G biosynthesis, click here
Glossary: (-)-(2S)-naringenin = (-)-(2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one
sophoraflavanone B = (-)-(2S)-8-dimethylallylnaringenin = (-)-(2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one
Other name(s): N8DT
Systematic name: dimethylallyl-diphosphate:naringenin 8-dimethylallyltransferase
Comments: Requires Mg2+. This membrane-bound protein is located in the plastids [2]. In addition to naringenin, the enzyme can prenylate several other flavanones at the C-8 position, but more slowly. Along with EC 1.14.13.103 (8-dimethylallylnaringenin 2′-hydroxylase) and EC 2.5.1.71 (leachianone G 2′′-dimethylallyltransferase), this enzyme forms part of the sophoraflavanone-G-biosynthesis pathway.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Yamamoto, H., Senda, M. and Inoue, K. Flavanone 8-dimethylallyltransferase in Sophora flavescens cell suspension cultures. Phytochemistry 54 (2000) 649–655. [PMID: 10975499]
2.  Zhao, P., Inoue, K., Kouno, I. and Yamamoto, H. Characterization of leachianone G 2′′-dimethylallyltransferase, a novel prenyl side-chain elongation enzyme for the formation of the lavandulyl group of sophoraflavanone G in Sophora flavescens Ait. cell suspension cultures. Plant Physiol. 133 (2003) 1306–1313. [PMID: 14551337]
[EC 2.5.1.70 created 2007]
 
 


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