| EC |
2.5.1.68 |
| Accepted name: |
(2Z,6E)-farnesyl diphosphate synthase |
| Reaction: |
geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2Z,6E)-farnesyl diphosphate |
|
For diagram of trans-polycis-polyprenol diphosphate biosynthesis, click here |
| Other name(s): |
(Z)-farnesyl diphosphate synthase; Z-farnesyl diphosphate synthase |
| Systematic name: |
geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase |
| Comments: |
Requires Mg2+ or Mn2+ for activity. The product of this reaction is an intermediate in the synthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of most features of the mycobacterial cell wall, including peptidoglycan, linker unit galactan and arabinan. Neryl diphosphate can also act as substrate. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Schulbach, M.C., Mahapatra, S., Macchia, M., Barontini, S., Papi, C., Minutolo, F., Bertini, S., Brennan, P.J. and Crick, D.C. Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis. J. Biol. Chem. 276 (2001) 11624–11630. [DOI] [PMID: 11152452] |
|
| [EC 2.5.1.68 created 2007, modified 2010] |
| |
|
| |
|
Printable version