| EC |
2.5.1.6 |
| Accepted name: |
methionine adenosyltransferase |
| Reaction: |
ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine |
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For diagram of reaction, click here |
| Other name(s): |
adenosylmethionine synthetase; ATP-methionine adenosyltransferase; methionine S-adenosyltransferase; methionine-activating enzyme; S-adenosyl-L-methionine synthetase; S-adenosylmethionine synthase; S-adenosylmethionine synthetase; AdoMet synthetase |
| Systematic name: |
ATP:L-methionine S-adenosyltransferase |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9012-52-6 |
| References: |
| 1. |
Cantoni, G.L. S-Adenosylmethionine: A new intermediate formed enzymatically from L-methionine and adenosinetriphosphate. J. Biol. Chem. 204 (1953) 403–416. [PMID: 13084611] |
| 2. |
Cantoni, G.L. and Durell, J. Activation of methionine for transmethylation. II. The methionine-activating enzyme: studies on the mechanism of reaction. J. Biol. Chem. 225 (1957) 1033–1048. [PMID: 13416303] |
| 3. |
Mudd, S.H. and Cantoni, G.L. Activation of methionine for transmethylation. III. The methionine-activating enzyme of bakers' yeast. J. Biol. Chem. 231 (1958) 481–492. [PMID: 13538985] |
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| [EC 2.5.1.6 created 1961 as EC 2.4.2.13, transferred 1965 to EC 2.5.1.6] |
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