The Enzyme Database

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EC 2.5.1.38     
Accepted name: isonocardicin synthase
Reaction: S-adenosyl-L-methionine + nocardicin G = S-methyl-5′-thioadenosine + isonocardicin C
For diagram of nocardicin biosynthesis, click here
Other name(s): nocardicin aminocarboxypropyltransferase; S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase
Systematic name: S-adenosyl-L-methionine:nocardicin-G 3-amino-3-carboxypropyltransferase
Comments: The enzyme, characterized from the bacterium Nocardia uniformis, is involved in the biosynthesis of the β-lactam antibiotic nocardicin A. The enzyme can act on nocardicin E, F, and G, producing isonocardicin A, B, and C, respectively. However, the in vivo substrate is believed to be nocardicin G [3].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 118246-74-5
References:
1.  Wilson, B.A., Bantia, S., Salituro, G.M., Reeve, A.M. and Townsend, C.A. Cell-free biosynthesis of nocardicin A from nocardicin E and S-adenosylmethionine. J. Am. Chem. Soc. 110 (1988) 8238–8239.
2.  Reeve, A.M., Breazeale, S.D. and Townsend, C.A. Purification, characterization, and cloning of an S-adenosylmethionine-dependent 3-amino-3-carboxypropyltransferase in nocardicin biosynthesis. J. Biol. Chem. 273 (1998) 30695–30703. [PMID: 9804844]
3.  Kelly, W.L. and Townsend, C.A. Mutational analysis of nocK and nocL in the nocardicin a producer Nocardia uniformis. J. Bacteriol. 187 (2005) 739–746. [PMID: 15629944]
[EC 2.5.1.38 created 1992, modified 2016]
 
 


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