The Enzyme Database

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EC 2.5.1.139     
Accepted name: umbelliferone 6-dimethylallyltransferase
Reaction: dimethylallyl diphosphate + umbelliferone = diphosphate + demethylsuberosin
For diagram of psoralen biosynthesis, click here
Glossary: demethylsuberosin = 7-hydroxy-6-prenyl-1-benzopyran-2-one
osthenol = 7-hydroxy-8-prenyl-1-benzopyran-2-one
Other name(s): PcPT
Systematic name: dimethylallyl diphosphate:umbelliferone 6-dimethylallyltransferase
Comments: The enzyme from parsley (Petroselinum crispum) is specific for umbelliferone and dimethylallyl diphosphate. A minor product is osthenol, which is produced by transfer of the dimethylallyl group to C-8 of umbelliferone.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Hamerski, D., Schmitt, D. and Matern, U. Induction of two prenyltransferases for the accumulation of coumarin phytoalexins in elicitor-treated Ammi majus cell suspension cultures. Phytochemistry 29 (1990) 1131–1135. [PMID: 1366425]
2.  Karamat, F., Olry, A., Munakata, R., Koeduka, T., Sugiyama, A., Paris, C., Hehn, A., Bourgaud, F. and Yazaki, K. A coumarin-specific prenyltransferase catalyzes the crucial biosynthetic reaction for furanocoumarin formation in parsley. Plant J. 77 (2014) 627–638. [PMID: 24354545]
[EC 2.5.1.139 created 2017]
 
 


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