The Enzyme Database

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EC 2.5.1.119     
Accepted name: β-(isoxazolin-5-on-4-yl)-L-alanine synthase
Reaction: O-acetyl-L-serine + isoxazolin-5-one = 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate
For diagram of O3-Acetyl-L-serine metabolism, click here
Systematic name: O-acetyl-L-serine:isoxazolin-5-one 4-(2-amino-2-carboxyethyl)transferase
Comments: 3-(5-Oxoisoxazolin-4-yl)-L-alanine is an antifungal antibiotic produced by the bacterium Streptomyces platensis. The enzymes from the plants Lathyrus odoratus (sweet pea), L. sativus (grass pea) and Citrullus vulgaris (watermelon) that catalyse EC 2.5.1.118 (β-(isoxazolin-5-on-2-yl)-L-alanine synthase) also catalyse this reaction in vitro, but not in vivo. Closely related and possibly identical to EC 2.5.1.47, cysteine synthase, and EC 2.5.1.51, β-pyrazolylalanine synthase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Ikegami, F., Kamiya, M., Kuo, Y.H., Lambein, F. and Murakoshi, I. Enzymatic synthesis of two isoxazolylalanine isomers by cysteine synthases in Lathyrus species. Biol. Pharm. Bull. 19 (1996) 1214–1215. [PMID: 8889043]
[EC 2.5.1.119 created 2014]
 
 


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