The Enzyme Database

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EC 2.4.99.6     
Accepted name: N-acetyllactosaminide α-2,3-sialyltransferase
Reaction: CMP-N-acetylneuraminate + β-D-galactosyl-(1→4)-N-acetyl-D-glucosaminyl-glycoprotein = CMP + α-N-acetylneuraminyl-(2→3)-β-D-galactosyl-(1→4)-N-acetyl-D-glucosaminyl-glycoprotein
Other name(s): sialyltransferase; cytidine monophosphoacetylneuraminate-β-galactosyl(1→4)acetylglucosaminide α2→3-sialyltransferase; α2→3 sialyltransferase; SiaT; CMP-N-acetylneuraminate:β-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein α-2,3-N-acetylneuraminyltransferase
Systematic name: CMP-N-acetylneuraminate:β-D-galactosyl-(1→4)-N-acetyl-D-glucosaminyl-glycoprotein α-(2→3)-N-acetylneuraminyltransferase
Comments: Acts on β-D-galactosyl-1,4-N-acetyl-D-glucosaminyl termini on glycoprotein.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 77537-85-0
References:
1.  Van den Eijnden, D.H. and Schiphorst, W.E.C.M. Detection of β-galactosyl(1→4)N-acetylglucosaminide α(2→3)-sialyltransferase activity in fetal calf liver and other tissues. J. Biol. Chem. 256 (1981) 3159–3162. [PMID: 7204397]
[EC 2.4.99.6 created 1984, modified 1986]
 
 


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