The Enzyme Database

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EC 2.4.99.11     
Accepted name: lactosylceramide α-2,6-N-sialyltransferase
Reaction: CMP-N-acetylneuraminate + β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide = CMP + α-N-acetylneuraminyl-(2→6)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide
For diagram of ganglioside biosynthesis (pathway to GM2), click here
Glossary: lactosylceramide = β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide
Other name(s): cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase; CMP-acetylneuraminate-lactosylceramide-sialyltransferase; CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase; CMP-sialic acid:lactosylceramide sialyltransferase; CMP-N-acetylneuraminate:lactosylceramide α-2,6-N-acetylneuraminyltransferase; CMP-N-acetylneuraminate:β-D-galactosyl-(1→4)-β-D-glucosyl(1↔1)ceramide α-(2→6)-N-acetylneuraminyltransferase
Systematic name: CMP-N-acetylneuraminate:β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide α-(2→6)-N-acetylneuraminyltransferase
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 55071-95-9
References:
1.  Albarracin, I., Lassaga, F.E. and Caputto, R. Purification and characterization of an endogenous inhibitor of the sialyltransferase CMP-N-acetylneuraminate: lactosylceramide α2,6-N-acetylneuraminyltransferase (EC 2.4.99.-). Biochem. J. 254 (1988) 559–565. [PMID: 2460092]
2.  Landa, C.A., Maccioni, H.J.F., Arce, A. and Caputto, R. The biosynthesis of brain gangliosides. Separation of membranes with different ratios of ganglioside sialylating activity to gangliosides. Biochem. J. 168 (1977) 325–332. [PMID: 606237]
[EC 2.4.99.11 created 1992]
 
 


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