The Enzyme Database

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EC 2.4.2.7     
Accepted name: adenine phosphoribosyltransferase
Reaction: AMP + diphosphate = adenine + 5-phospho-α-D-ribose 1-diphosphate
For diagram of ribose activation, click here
Other name(s): AMP pyrophosphorylase; transphosphoribosidase; APRT; AMP-pyrophosphate phosphoribosyltransferase; adenine phosphoribosylpyrophosphate transferase; adenosine phosphoribosyltransferase; adenylate pyrophosphorylase; adenylic pyrophosphorylase
Systematic name: AMP:diphosphate phospho-D-ribosyltransferase
Comments: 5-Amino-4-imidazolecarboxamide can replace adenine.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9027-80-9
References:
1.  Flaks, J.G., Erwin, M.J. and Buchanan, J.M. Biosynthesis of the purines. XVI. The synthesis of adenosine 5′-phosphate and 5-amino-4-imidazolecarboxamide ribotide by a nucleotide pyrophosphorylase. J. Biol. Chem. 228 (1957) 201–213. [PMID: 13475309]
2.  Kornberg, A., Lieberman, I. and Simms, E.S. Enzymatic synthesis of purine nucleotides. J. Biol. Chem. 215 (1955) 417–427. [PMID: 14392175]
3.  Lukens, L.N. and Herrington, K.A. Enzymic formation of 6-mercaptopurine ribotide. Biochim. Biophys. Acta 24 (1957) 432–433. [PMID: 13436452]
[EC 2.4.2.7 created 1961]
 
 


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