The Enzyme Database

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EC 2.4.2.55     
Accepted name: nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase
Reaction: nicotinate D-ribonucleotide + phenol = nicotinate + phenyl 5-phospho-α-D-ribofuranoside
Other name(s): ArsAB
Systematic name: nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase
Comments: The enzyme is involved in the biosynthesis of phenolic cobamides in the Gram-positive bacterium Sporomusa ovata. It can also transfer the phospho-D-ribosyl group to 4-methylphenol and 5,6-dimethylbenzimidazole. The related EC 2.4.2.21, nicotinate-nucleotide dimethylbenzimidazole phosphoribosyltransferase, also transfers the phospho-D-ribosyl group from nicotinate D-ribonucleotide to 5,6-dimethylbenzimidazole, but shows no activity with 4-methylphenol or phenol.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Chan, C.H. and Escalante-Semerena, J.C. ArsAB, a novel enzyme from Sporomusa ovata activates phenolic bases for adenosylcobamide biosynthesis. Mol. Microbiol. 81 (2011) 952–967. [PMID: 21696461]
[EC 2.4.2.55 created 2013]
 
 


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