ExplorEnz: EC 2.4.2.49

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2.4.2.49

Accepted name:

neamine phosphoribosyltransferase

Reaction:

neamine + 5-phospho-α-D-ribose 1-diphosphate = 5′′-phosphoribostamycin + diphosphate

For diagram of neamine and ribostamycin biosynthesis, click here

Glossary:

neamine = (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}oxane-3,4-diol
ribostamycin = (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2-{[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}oxane-3,4-diol

Other name(s):

btrL (gene name); neoM (gene name)

Systematic name:

neamine:5-phospho-α-D-ribose 1-diphosphate phosphoribosyltransferase

Comments:

Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including ribostamycin, neomycin and butirosin. The enzyme requires a divalent metal ion, optimally Mg²⁺, Ni²⁺ or Co²⁺.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Kudo, F., Fujii, T., Kinoshita, S. and Eguchi, T. Unique O-ribosylation in the biosynthesis of butirosin. Bioorg. Med. Chem. 15 (2007) 4360–4368. [DOI] [PMID: 17482823]

[EC 2.4.2.49 created 2013]