The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 2.4.2.4     
Accepted name: thymidine phosphorylase
Reaction: thymidine + phosphate = thymine + 2-deoxy-α-D-ribose 1-phosphate
Other name(s): pyrimidine phosphorylase; thymidine-orthophosphate deoxyribosyltransferase; animal growth regulators, blood platelet-derived endothelial cell growth factors; blood platelet-derived endothelial cell growth factor; deoxythymidine phosphorylase; gliostatins; pyrimidine deoxynucleoside phosphorylase; thymidine:phosphate deoxy-D-ribosyltransferase
Systematic name: thymidine:phosphate deoxy-α-D-ribosyltransferase
Comments: The enzyme in some tissues also catalyses deoxyribosyltransferase reactions of the type catalysed by EC 2.4.2.6, nucleoside deoxyribosyltransferase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9030-23-3
References:
1.  Friedkin, M. and Roberts, D. The enzymatic synthesis of nucleosides. I. Thymidine phosphorylase in mammalian tissue. J. Biol. Chem. 207 (1954) 245–256. [PMID: 13152099]
2.  Zimmerman, M. and Seidenberg, J. Deoxyribosyl transfer. I. Thymidine phosphorylase and nucleoside deoxyribosyltransferase in normal and malignant tissues. J. Biol. Chem. 239 (1964) 2618–2621. [PMID: 14235544]
3.  Zimmerman, M. Deoxyribosyl transfer. II. Nucleoside:pyrimidine deoxyribosyltransferase activity of three partially purified thymidine phosphorylases. J. Biol. Chem. 239 (1964) 2622–2627. [PMID: 14235545]
[EC 2.4.2.4 created 1961]
 
 


Data © 2001–2014 IUBMB
Web site © 2005–2014 Andrew McDonald