The Enzyme Database

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EC 2.4.2.1     
Accepted name: purine-nucleoside phosphorylase
Reaction: (1) purine ribonucleoside + phosphate = purine + α-D-ribose 1-phosphate
(2) purine deoxyribonucleoside + phosphate = purine + 2-deoxy-α-D-ribose 1-phosphate
Other name(s): inosine phosphorylase; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase; purine ribonucleoside phosphorylase
Systematic name: purine-nucleoside:phosphate ribosyltransferase
Comments: Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9030-21-1
References:
1.  Agarwal, R.P. and Parks, R.E. Purine nucleoside phosphorylase from human erythrocytes. IV. Crystallization and some properties. J. Biol. Chem. 244 (1969) 644–647. [PMID: 5768862]
2.  Friedkin, M. and Kalckar, H. Nucleoside phosphorylases. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds), The Enzymes, 2nd edn, vol. 5, Academic Press, New York, 1961, pp. 237–255.
3.  Heppel, L.A. and Hilmoe, R.J. Phosphorolysis and hydrolysis of purine ribosides from yeast. J. Biol. Chem. 198 (1952) 683–694. [PMID: 12999785]
4.  Kalckar, H.M. The enzymatic synthesis of purine ribosides. J. Biol. Chem. 167 (1947) 477–486. [PMID: 20285042]
5.  Saunders, P.P., Wilson, B.A. and Saunders, G.F. Purification and comparative properties of a pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus. J. Biol. Chem. 244 (1969) 3691–3697. [PMID: 4978445]
6.  Tsuboi, K.K. and Hudson, P.B. Enzymes of the human erythrocyte. I. Purine nucleoside phosphorylase; isolation procedure. J. Biol. Chem. 224 (1957) 879–887. [PMID: 13405917]
[EC 2.4.2.1 created 1961]
 
 


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