| EC |
2.4.2.1 |
| Accepted name: |
purine-nucleoside phosphorylase |
| Reaction: |
(1) purine ribonucleoside + phosphate = purine + α-D-ribose 1-phosphate
(2) purine 2′-deoxyribonucleoside + phosphate = purine + 2-deoxy-α-D-ribose 1-phosphate |
| Other name(s): |
inosine phosphorylase; PNPase (ambiguous); PUNPI; PUNPII; inosine-guanosine phosphorylase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase; purine ribonucleoside phosphorylase |
| Systematic name: |
purine-nucleoside:phosphate ribosyltransferase |
| Comments: |
Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase. |
| Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9030-21-1 |
| References: |
| 1. |
Agarwal, R.P. and Parks, R.E. Purine nucleoside phosphorylase from human erythrocytes. IV. Crystallization and some properties. J. Biol. Chem. 244 (1969) 644–647. [PMID: 5768862] |
| 2. |
Friedkin, M. and Kalckar, H. Nucleoside phosphorylases. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Ed.), The Enzymes, 2nd edn, vol. 5, Academic Press, New York, 1961, pp. 237–255. |
| 3. |
Heppel, L.A. and Hilmoe, R.J. Phosphorolysis and hydrolysis of purine ribosides from yeast. J. Biol. Chem. 198 (1952) 683–694. [PMID: 12999785] |
| 4. |
Kalckar, H.M. The enzymatic synthesis of purine ribosides. J. Biol. Chem. 167 (1947) 477–486. [PMID: 20285042] |
| 5. |
Saunders, P.P., Wilson, B.A. and Saunders, G.F. Purification and comparative properties of a pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus. J. Biol. Chem. 244 (1969) 3691–3697. [PMID: 4978445] |
| 6. |
Tsuboi, K.K. and Hudson, P.B. Enzymes of the human erythrocyte. I. Purine nucleoside phosphorylase; isolation procedure. J. Biol. Chem. 224 (1957) 879–887. [PMID: 13405917] |
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| [EC 2.4.2.1 created 1961] |
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