EC |
2.4.1.83 |
Accepted name: |
dolichyl-phosphate β-D-mannosyltransferase |
Reaction: |
GDP-α-D-mannose + dolichyl phosphate = GDP + dolichyl β-D-mannosyl phosphate |
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For diagram of glycoprotein biosynthesis, click here |
Other name(s): |
GDP-Man:DolP mannosyltransferase; dolichyl mannosyl phosphate synthase; dolichyl-phospho-mannose synthase; GDP-mannose:dolichyl-phosphate mannosyltransferase; guanosine diphosphomannose-dolichol phosphate mannosyltransferase; dolichol phosphate mannose synthase; dolichyl phosphate mannosyltransferase; dolichyl-phosphate mannose synthase; GDP-mannose-dolichol phosphate mannosyltransferase; GDP-mannose-dolichylmonophosphate mannosyltransferase; mannosylphosphodolichol synthase; mannosylphosphoryldolichol synthase |
Systematic name: |
GDP-mannose:dolichyl-phosphate β-D-mannosyltransferase |
Comments: |
Acts only on long-chain polyprenyl phosphates and α-dihydropolyprenyl phosphates that are larger than C35. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 62213-44-9 |
References: |
1. |
Babczinski, P., Haselbeck, A. and Tanner, W. Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme. Eur. J. Biochem. 105 (1980) 509–515. [DOI] [PMID: 6989607] |
2. |
Bretthauer, R.K., Wu, S. and Irwin, W.E. Enzymatic transfer of mannose from guanosine diphosphate mannose to dolichol phosphate in yeast (Hansenula holstii). A possible step in mannan synthesis. Biochim. Biophys. Acta 304 (1973) 736–747. [DOI] [PMID: 4726855] |
3. |
Haselbeck, A. Purification of GDP mannose:dolichyl-phosphate O-β-D-mannosyltransferase from Saccharomyces cerevisiae. Eur. J. Biochem. 181 (1989) 663–668. [DOI] [PMID: 2659345] |
4. |
Palamarczyk, G., Lehle, L., Mankowski, T., Chojnacki, T. and Tanner, W. Specificity of solubilized yeast glycosyl transferases for polyprenyl derivatives. Eur. J. Biochem. 105 (1980) 517–523. [DOI] [PMID: 6445267] |
5. |
Richards, J.B. and Hemming, F.W. The transfer of mannose from guanosine diphosphate mannose to dolichol phosphate and protein by pig liver endoplasmic reticulum. Biochem. J. 130 (1972) 77–93. [PMID: 4655455] |
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[EC 2.4.1.83 created 1976, modified 1983] |
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