The Enzyme Database

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Accepted name: devancosaminyl-vancomycin vancosaminetransferase
Reaction: dTDP-β-L-vancosamine + devancosaminyl-vancomycin = dTDP + vancomycin
For diagram of chloroorienticin biosynthesis, click here
Glossary: dTDP-β-L-vancosamine = dTDP-3-amino-2,3,6-trideoxy-3-C-methyl-β-L-lyxo-hexopyranose
Other name(s): devancosaminyl-vancomycin TDP-vancosaminyltransferase; GtfD; dTDP-β-L-vancomycin:desvancosaminyl-vancomycin β-L-vancosaminetransferase; desvancosaminyl-vancomycin vancosaminetransferase
Systematic name: dTDP-β-L-vancomycin:devancosaminyl-vancomycin β-L-vancosaminetransferase
Comments: The enzyme, isolated from the bacterium Amycolatopsis orientalis, catalyses the ultimate step in the biosynthesis of the antibiotic vancomycin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Losey, H.C., Peczuh, M.W., Chen, Z., Eggert, U.S., Dong, S.D., Pelczer, I., Kahne, D. and Walsh, C.T. Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides. Biochemistry 40 (2001) 4745–4755. [PMID: 11294642]
2.  Mulichak, A.M., Lu, W., Losey, H.C., Walsh, C.T. and Garavito, R.M. Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands. Biochemistry 43 (2004) 5170–5180. [PMID: 15122882]
[EC created 2014]

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