The Enzyme Database

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EC 2.4.1.284     
Accepted name: 2-deoxystreptamine glucosyltransferase
Reaction: UDP-α-D-glucose + 2-deoxystreptamine = UDP + 2′-deamino-2′-hydroxyparomamine
Glossary: 2′-deamino-2′-hydroxyparomamine = 4-O-α-D-glucopyranosyl-2-deoxy-D-streptamine
Other name(s): kanF (gene name)
Systematic name: UDP-α-D-glucose:2-deoxystreptamine 6-α-D-glucosyltransferase
Comments: Involved in the biosynthesis of kanamycin B and kanamycin C. Also catalyses EC 2.4.1.283, 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase, but activity is only one fifth of that with UDP-α-D-glucose.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Park, J.W., Park, S.R., Nepal, K.K., Han, A.R., Ban, Y.H., Yoo, Y.J., Kim, E.J., Kim, E.M., Kim, D., Sohng, J.K. and Yoon, Y.J. Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation. Nat. Chem. Biol. 7 (2011) 843–852. [PMID: 21983602]
[EC 2.4.1.284 created 2012]
 
 


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