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Accepted name: α-1,3-mannosyl-glycoprotein 4-β-
N-acetyl- D-glucosamine + 3-(2-[ N-acetyl-β- D-glucosaminyl]-α- D-mannosyl)-β- D-mannosyl-R = UDP + 3-(2,4-bis[ N-acetyl-β- D-glucosaminyl]-α- D-mannosyl)-β- D-mannosyl-R
For diagram of reaction,
N-acetylglucosaminyltransferase IV; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV; β-acetylglucosaminyltransferase IV; uridine diphosphoacetylglucosamine-glycopeptide β4-acetylglucosaminyltransferase IV; α-1,3-mannosylglycoprotein β-1,4- N-acetylglucosaminyltransferase; GnTIV
Systematic name: UDP-
N-acetyl- D-glucosamine:3-[2-( N-acetyl-β- D-glucosaminyl)-α- D-mannosyl]-glycoprotein 4-β- N-acetyl- D-glucosaminyltransferase
Comments: R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor (
click here for diagram). The best acceptor for this enzyme is probably the same as that favoured by EC 22.214.171.124, β-1,4-mannosyl-glycoprotein 4-β- N-acetylglucosaminyltransferase.
Links to other databases:
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 86498-16-0
Gleeson, P.A. and Schachter, H. Control of glycoprotein synthesis.
J. Biol. Chem. 258 (1983) 6162–6173. [PMID: 6222042]
[EC 126.96.36.199 created 1984, modified 2001 (EC 188.8.131.52 created 1972, part incorporated 1984)]
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