| EC |
2.4.1.133 |
| Accepted name: |
xylosylprotein 4-β-galactosyltransferase |
| Reaction: |
UDP-galactose + O-β-D-xylosylprotein = UDP + 4-β-D-galactosyl-O-β-D-xylosylprotein |
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For diagram of the early stages of heparan and chondroitin biosynthesis, click here |
| Other name(s): |
UDP-D-galactose:D-xylose galactosyltransferase; UDP-D-galactose:xylose galactosyltransferase; galactosyltransferase I; uridine diphosphogalactose-xylose galactosyltransferase |
| Systematic name: |
UDP-galactose:O-β-D-xylosylprotein 4-β-D-galactosyltransferase |
| Comments: |
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+. |
| Links to other databases: |
BRENDA, EXPASY, IUBMB, KEGG, CAS registry number: 52227-72-2 |
| References: |
| 1. |
Schwartz, N.B. and Roden, L. Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltransferase. J. Biol. Chem. 250 (1975) 5200–5207. [PMID: 1150655] |
| 2. |
Okajima, T., Yoshida, K., Kondo, T. and Furukawa, K. Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans. J. Biol. Chem. 274 (1999) 22915–22918. [PMID: 10438455] |
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| [EC 2.4.1.133 created 1984, modified 2002] |
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