The Enzyme Database

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EC 2.3.3.17     
Accepted name: methylthioalkylmalate synthase
Reaction: an ω-(methylthio)-2-oxoalkanoate + acetyl-CoA + H2O = a 2-[ω-(methylthio)alkyl]malate + CoA
For diagram of L-Homomethionine biosynthesis, click here
Other name(s): MAM1 (gene name); MAM3 (gene name)
Systematic name: acetyl-CoA:ω-(methylthio)-2-oxoalkanoate C-acetyltransferase
Comments: The enzyme, characterized from the plant Arabidopsis thaliana, is involved in the L-methionine side-chain elongation pathway, forming substrates for the biosynthesis of aliphatic glucosinolates. Two forms are known - MAM1 catalyses only only the first two rounds of methionine chain elongation, while MAM3 catalyses all six cycles, up to formation of L-hexahomomethionine.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Textor, S., Bartram, S., Kroymann, J., Falk, K.L., Hick, A., Pickett, J.A. and Gershenzon, J. Biosynthesis of methionine-derived glucosinolates in Arabidopsis thaliana: recombinant expression and characterization of methylthioalkylmalate synthase, the condensing enzyme of the chain-elongation cycle. Planta 218 (2004) 1026–1035. [PMID: 14740211]
2.  Textor, S., de Kraker, J.W., Hause, B., Gershenzon, J. and Tokuhisa, J.G. MAM3 catalyzes the formation of all aliphatic glucosinolate chain lengths in Arabidopsis. Plant Physiol. 144 (2007) 60–71. [PMID: 17369439]
[EC 2.3.3.17 created 2016]
 
 


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