The Enzyme Database

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Accepted name: peptide α-N-acetyltransferase
Reaction: acetyl-CoA + peptide = CoA + Nα-acetylpeptide
Other name(s): β-endorphin acetyltransferase; peptide acetyltransferase; protein N-terminal acetyltransferase; NAT; Nα-acetyltransferase; amino-terminal amino acid-acetylating enzyme; acetyl-CoA:peptide α-N-acetyltransferase
Systematic name: acetyl-CoA:peptide Nα-acetyltransferase
Comments: Acetylates N-terminal alanine, serine, methionine and glutamate residues in a number of peptides and proteins, including β-endorphin, corticotropins and melanotropin. cf. EC α-tubulin N-acetyltransferase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 116155-74-9
1.  Driessen, H.P.C., Tesser, G.I. and Bloemendal, H. The mechanism of N-terminal acetylation of proteins. CRC Crit. Rev. Biochem. 18 (1985) 281. [PMID: 3902358]
2.  Glembotski, C.C. Characterization of the peptide acetyltransferase activity in bovine and rat intermediate pituitaries responsible for the acetylation of β-endorphin and α-melanotropin. J. Biol. Chem. 257 (1982) 10501–10509. [PMID: 6286657]
3.  O'Donohue, T.L. Identification of endorphin acetyltransferase in rat brain and pituitary gland. J. Biol. Chem. 258 (1983) 2163–2167. [PMID: 6296134]
4.  Tsunasawa, S., Kamitani, K. and Norita, K. Partial purification and properties of the amino-terminal amino acid-acetylating enzyme from hen's oviduct. J. Biochem. (Tokyo) 87 (1980) 645–650. [PMID: 6244269]
[EC created 1986, modified 1989]

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