| EC |
2.3.1.86 |
| Accepted name: |
fatty-acyl-CoA synthase |
| Reaction: |
acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = long-chain-acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+ |
| Other name(s): |
yeast fatty acid synthase |
| Systematic name: |
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing) |
| Comments: |
The yeast enzyme is a multi-functional protein catalysing the reactions of EC 2.3.1.38 [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39 [acyl-carrier-protein] S-malonyltransferase, EC 2.3.1.41 3-oxoacyl-[acyl-carrier-protein] synthase, EC 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase, EC 1.1.1.279, (R)-3-hydroxyacid ester dehydrogenase, EC 4.2.1.59 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase and EC 1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, METACYC, PDB, CAS registry number: 94219-29-1 |
| References: |
| 1. |
Schweitzer, E., Kniep, B., Castorph, H. and Holzner, U. Pantetheine-free mutants of the yeast fatty-acid-synthetase complex. Eur. J. Biochem. 39 (1973) 353–362. [PMID: 4590449] |
| 2. |
Wakil, S.J., Stoops, J.K. and Joshi, V.C. Fatty acid synthesis and its regulation. Annu. Rev. Biochem. 52 (1983) 537–579. [PMID: 6137188] |
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| [EC 2.3.1.86 created 1984, modified 2003] |
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