The Enzyme Database

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EC 2.3.1.81     
Accepted name: aminoglycoside 3-N-acetyltransferase
Reaction: acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N3-acetyl-2-deoxystreptamine antibiotic
For diagram of neamine and ribostamycin biosynthesis, click here
Glossary: kanamycin
Other name(s): 3-aminoglycoside acetyltransferase; 3-N-aminoglycoside acetyltransferase; aminoglycoside N3-acetyltransferase; acetyl-CoA:2-deoxystreptamine-antibiotic N3′-acetyltransferase (incorrect); aminoglycoside N3′-acetyltransferase (incorrect)
Systematic name: acetyl-CoA:2-deoxystreptamine-antibiotic N3-acetyltransferase
Comments: Different from EC 2.3.1.60 gentamicin 3-N-acetyltransferase. A wide range of antibiotics containing the 2-deoxystreptamine ring can act as acceptors, including gentamicin, kanamycin, tobramycin, neomycin and apramycin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 60120-42-5
References:
1.  Davies, J. and O'Connor, S. Enzymatic modification of aminoglycoside antibiotics: 3-N-Acetyltransferase with broad specificity that determines resistance to the novel aminoglycoside apramycin. Antimicrob. Agents Chemother. 14 (1978) 69–72. [PMID: 356726]
[EC 2.3.1.81 created 1984, modified 2015]
 
 


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