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Accepted name: phosphatidylcholine—sterol
Reaction: phosphatidylcholine + a sterol = 1-acylglycerophosphocholine + a sterol ester
Other name(s): lecithin—cholesterol acyltransferase; phospholipid—cholesterol acyltransferase; LCAT (lecithin-cholesterol acyltransferase); lecithin:cholesterol acyltransferase; lysolecithin acyltransferase
Systematic name: phosphatidylcholine:sterol
Comments: Palmitoyl, oleoyl and linoleoyl residues can be transferred; a number of sterols, including cholesterol, can act as acceptors. The bacterial enzyme also catalyses the reactions of
EC 220.127.116.11 phospholipase A and 2 EC 18.104.22.168 lysophospholipase.
Links to other databases:
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9031-14-5
Bartlett, K., Keat, M.J. and Mercer, E.I. Biosynthesis of sterol esters in
Phycomyces blakesleeanus. Phytochemistry 13 (1974) 1107–1113.
Buckley, J.T., Halasa, L.N. and Macintyre, S. Purification and partial characterization of a bacterial phospholipid: cholesterol acyltransferase.
J. Biol. Chem. 257 (1982) 3320–3325. [PMID: 7061477]
Glomset, J.A.J. The plasma lecithins:cholesterol acyltransferase reaction.
Lipid Res. 9 (1968) 155–167. [PMID: 4868699]
Vahouny, G.V. and Tradwell, C.R. Enzymatic synthesis and hydrolysis of cholesterol esters.
Methods Biochem. Anal. 16 (1968) 219–272. [PMID: 4877146]
[EC 22.214.171.124 created 1972, modified 1976]
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