EC |
2.3.1.308 |
Accepted name: |
tubulin N-terminal N-acetyltransferase NAT9 |
Reaction: |
acetyl-CoA + an N-terminal-L-methionyl-[tubulin] = an N-terminal-Nα-acetyl-L-methionyl-[tubulin] + CoA |
Other name(s): |
NAT9 (gene name); microtubule-associated N-acetyltransferase NAT9 |
Systematic name: |
acetyl-CoA:N-terminal-Met-[tubulin] Met-Nα-acetyltransferase |
Comments: |
The enzyme, characterized from the fruit fly (Drosophila melanogaster), acetylates the N-terminal of both α- and β-tubulin. The enzyme acts cotranslationally, and can't act on a preformed tubulin α/β heterodimer. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Mok, J.W. and Choi, K.W. Novel function of N-acetyltransferase for microtubule stability and JNK signaling in Drosophila organ development. Proc. Natl. Acad. Sci. USA 118 (2021) . [DOI] [PMID: 33479178] |
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[EC 2.3.1.308 created 2022] |
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