The Enzyme Database

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EC 2.3.1.247     
Accepted name: 3-keto-5-aminohexanoate cleavage enzyme
Reaction: (5S)-5-amino-3-oxohexanoate + acetyl-CoA = L-3-aminobutanoyl-CoA + acetoacetate
For diagram of lysine catabolism, click here
Glossary: L-3-aminobutyryl-CoA = (3S)-3-aminobutanoyl-CoA
Other name(s): kce (gene name)
Systematic name: (5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase
Comments: Requires Zn2+. The enzyme, isolated from the bacteria Fusobacterium nucleatum and Cloacimonas acidaminovorans, is involved in the anaerobic fermentation of lysine.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Barker, H.A., Kahn, J.M. and Hedrick, L. Pathway of lysine degradation in Fusobacterium nucleatum. J. Bacteriol. 152 (1982) 201–207. [PMID: 6811551]
2.  Kreimeyer, A., Perret, A., Lechaplais, C., Vallenet, D., Medigue, C., Salanoubat, M. and Weissenbach, J. Identification of the last unknown genes in the fermentation pathway of lysine. J. Biol. Chem. 282 (2007) 7191–7197. [PMID: 17166837]
3.  Bellinzoni, M., Bastard, K., Perret, A., Zaparucha, A., Perchat, N., Vergne, C., Wagner, T., de Melo-Minardi, R.C., Artiguenave, F., Cohen, G.N., Weissenbach, J., Salanoubat, M. and Alzari, P.M. 3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation. J. Biol. Chem. 286 (2011) 27399–27405. [PMID: 21632536]
[EC 2.3.1.247 created 2015]
 
 


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