EC |
2.3.1.208 |
Accepted name: |
4-hydroxycoumarin synthase |
Reaction: |
malonyl-CoA + 2-hydroxybenzoyl-CoA = 2 CoA + 4-hydroxycoumarin + CO2 |
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For diagram of polyketides biosynthesis, click here |
Glossary: |
2-hydroxybenzoyl-CoA = salicyloyl-CoA |
Other name(s): |
BIS2; BIS3 |
Systematic name: |
malonyl-CoA:2-hydroxybenzoyl-CoA malonyltransferase |
Comments: |
The enzyme, a polyketide synthase, can also accept benzoyl-CoA as substrate, which it condenses with 3 malonyl-CoA molecules to form 3,5-dihydroxybiphenyl (cf. EC 2.3.1.177, biphenyl synthase) [1]. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Liu, B., Raeth, T., Beuerle, T. and Beerhues, L. A novel 4-hydroxycoumarin biosynthetic pathway. Plant Mol. Biol. 72 (2010) 17–25. [DOI] [PMID: 19757094] |
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[EC 2.3.1.208 created 2012] |
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