The Enzyme Database

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EC 2.3.1.200     
Accepted name: lipoyl amidotransferase
Reaction: [glycine cleavage system H]-N6-lipoyl-L-lysine + a [lipoyl-carrier protein] = glycine cleavage system H + a [lipoyl-carrier protein]-N6-lipoyl-L-lysine
Glossary: lipoic acid = 5-[(3R)-1,2-dithiolan-3-yl]pentanoic acid
Other name(s): LipL (gene name, ambiguous)
Systematic name: [glycine cleavage system H]-N6-lipoyl-L-lysine:[lipoyl-carrier protein]-N6-L-lysine lipoyltransferase
Comments: In the bacterium Listeria monocytogenes the enzyme takes part in a pathway for scavenging of lipoic acid. The enzyme is bound to 2-oxo-acid dehydrogenases such as the pyruvate dehydrogenase complex, where it transfers the lipoyl moiety from lipoyl-[glycine cleavage system H] to the E2 subunits of the complexes.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Christensen, Q.H., Hagar, J.A., O'Riordan, M.X. and Cronan, J.E. A complex lipoate utilization pathway in Listeria monocytogenes. J. Biol. Chem. 286 (2011) 31447–31456. [PMID: 21768091]
[EC 2.3.1.200 created 2012]
 
 


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