EC |
2.3.1.177 |
Accepted name: |
3,5-dihydroxybiphenyl synthase |
Reaction: |
3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2 |
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For diagram of polyketides biosynthesis, click here |
Other name(s): |
BIS1; biphenyl synthase (ambiguous) |
Systematic name: |
malonyl-CoA:benzoyl-CoA malonyltransferase |
Comments: |
A polyketide synthase that is involved in the production of the phytoalexin aucuparin. 2-Hydroxybenzoyl-CoA can also act as substrate but it leads to the derailment product 4-hydroxycoumarin (cf. EC 2.3.1.208, 4-hydroxycoumarin synthase) [2]. This enzyme uses the same starter substrate as EC 2.3.1.151, benzophenone synthase. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 1217551-24-0 |
References: |
1. |
Liu, B., Beuerle, T., Klundt, T. and Beerhues, L. Biphenyl synthase from yeast-extract-treated cell cultures of Sorbus aucuparia. Planta 218 (2004) 492–496. [DOI] [PMID: 14595561] |
2. |
Liu, B., Raeth, T., Beuerle, T. and Beerhues, L. Biphenyl synthase, a novel type III polyketide synthase. Planta 225 (2007) 1495–1503. [DOI] [PMID: 17109150] |
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[EC 2.3.1.177 created 2006, modified 2012] |
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