The Enzyme Database

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EC 2.3.1.170     
Accepted name: 6′-deoxychalcone synthase
Reaction: 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O
For diagram of daidzein biosynthesis, click here
Glossary: isoliquiritigenin = 4,2′,4′-trihydroxychalcone
liquiritigenin = 7,4′-dihydroxyflavanone
Systematic name: malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing)
Comments: Isoliquiritigenin is the precursor of liquiritigenin, a 5-deoxyflavanone.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 114308-23-5
References:
1.  Ayabe, S., Udagawa, A. and Furuya, T. NAD(P)H-dependent 6′-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract. Arch. Biochem. Biophys. 261 (1988) 458–462. [PMID: 3355160]
[EC 2.3.1.170 created 2004]
 
 


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