The Enzyme Database

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EC 2.3.1.166     
Accepted name: 2α-hydroxytaxane 2-O-benzoyltransferase
Reaction: benzoyl-CoA + 10-deacetyl-2-debenzoylbaccatin III = CoA + 10-deacetylbaccatin III
For diagram of taxol biosynthesis, click here
Other name(s): benzoyl-CoA:taxane 2α-O-benzoyltransferase
Systematic name: benzoyl-CoA:taxan-2α-ol O-benzoyltransferase
Comments: The enzyme was studied using the semisynthetic substrate 2-debenzoyl-7,13-diacetylbaccatin III. It will not acylate the hydroxy group at 1β, 7β, 10β or 13α of 10-deacetyl baccatin III, or at 2α or 5α of taxa-4(20),11-diene-2α,5α-diol.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 329318-50-5
References:
1.  Walker, K. and Croteau, R. Taxol biosynthesis: molecular cloning of a benzoyl-CoA:taxane 2α-O-benzoyltransferase cDNA from taxus and functional expression in Escherichia coli. Proc. Natl. Acad. Sci. USA 97 (2000) 13591. [PMID: 11095755]
[EC 2.3.1.166 created 2002]
 
 


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