The Enzyme Database

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Accepted name: 6-methylsalicylic-acid synthase
Reaction: acetyl-CoA + 3 malonyl-CoA + NADPH + H+ = 6-methylsalicylate + 4 CoA + 3 CO2 + NADP+ + H2O
For diagram of polyketides biosynthesis, click here
Other name(s): MSAS; 6-methylsalicylic acid synthase
Systematic name: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing)
Comments: A multienzyme complex with a 4′-phosphopantetheine prosthetic group on the acyl carrier protein. It has a similar sequence to vertebrate type I fatty acid synthase. Acetoacetyl-CoA can also act as a starter molecule.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9045-37-8
1.  Spencer, J.B. and Jordan, P.M. Purification and properties of 6-methylsalicylic acid synthase from Penicillium patulum. Biochem. J. 288 (1992) 839–846. [PMID: 1471999]
2.  Child, C.J., Spencer, J.B., Bhogal, P. and Shoolingin-Jordan, P.M. Structural similarities between 6-methylsalicylic acid synthase from Penicillium patulum and vertebrate type I fatty acid synthase: evidence from thiol modification studies. Biochemistry 35 (1996) 12267–12274. [PMID: 8823160]
3.  Richardson, M.T., Pohl, N.L., Kealey, J.T. and Khosla, C. Tolerance and specificity of recombinant 6-methylsalicyclic acid synthase. Metab. Eng. 1 (1999) 180–187. [PMID: 10935930]
[EC created 2002]

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