ExplorEnz: EC 2.3.1.159

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2.3.1.159

Accepted name:

acridone synthase

Reaction:

3 malonyl-CoA + N-methylanthraniloyl-CoA = 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO₂

For diagram of acridone alkaloid biosynthesis, click here

Systematic name:

malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)

Comments:

Belongs to a superfamily of plant polyketide synthases. Has many similarities to chalcone and stilbene synthases (see reaction synthesis)

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 99085-53-7

References:

1.	Baumert, A., Maier, W., Gröger, D. and Deutzmann, R. Purification and properties of acridone synthase from cell suspension cultures of Ruta graveolens L. Z. Naturforsch. C: Biosci. 49 (1994) 26–32. [PMID: 8148006]
2.	Maier, W., Baumert, A., Schumann, B., Furukawa, H. and Gröger, D. Synthesis of 1,3-dihydroxy-N-methylacridone and its conversion to rutacridone by cell-free extracts of Ruta-graveolens cell cultures. Phytochemistry 32 (1993) 691–698.
3.	Lukačin, R., Springob, K., Urbanke, C., Ernwein, C., Schroder, G., Schroder, J. and Matern, U. Native acridone synthases I and II from Ruta graveolens L. form homodimers. FEBS Lett. 448 (1999) 135–140. [DOI] [PMID: 10217426]
4.	Junghanns, K.T., Kneusel, R.E., Groger, D. and Matern, U. Differential regulation and distribution of acridone synthase in Ruta graveolens. Phytochemistry 49 (1998) 403–411. [DOI] [PMID: 9747538]

[EC 2.3.1.159 created 2002]