| EC |
2.3.1.148 |
| Accepted name: |
glycerophospholipid acyltransferase (CoA-dependent) |
| Reaction: |
1-organyl-2-acyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine = 1-organyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-organyl-2-lyso-sn-glycero-3-phosphocholine |
| Systematic name: |
1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine acyltransferase (CoA-dependent) |
| Comments: |
Catalyses the transfer of fatty acids from intact choline- or ethanolamine-containing glycerophospholipids to the sn-2 position of a lyso-glycerophospholipid. The organyl group on sn-1 of the donor or acceptor molecule can be alkyl, acyl or alk-1-enyl. The term 'radyl' has sometimes been used to refer to such substituting groups. Differs from EC 2.3.1.147 glycerophospholipid arachidonoyl-transferase (CoA-independent) in requiring CoA and not favouring the transfer of polyunsaturated acyl groups. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9054-54-0 |
| References: |
| 1. |
Irvine, R.F., Dawson, R.M.C. Transfer of arachidonic acid between phospholipids in rat liver microsomes. Biochem. Biophys. Res. Commun. 91 (1979) 1399–1405. [DOI] [PMID: 526311] |
| 2. |
Robinson, M., Blank, M.L., Snyder, F. Acylation of lysophospholipids by rabbit alveolar macrophages. Specific CoA-dependent and CoA-independent reactions. J. Biol. Chem. 260 (1985) 7889–7895. [PMID: 4008481] |
| 3. |
Snyder, F., Lee, T.C., Blank, M.L. The role of transacylases in the metabolism of arachidonate and platelet-activating factor. Prog. Lipid Res. 31 (1992) 65–86. [DOI] [PMID: 1641397] |
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| [EC 2.3.1.148 created 1999] |
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