The Enzyme Database

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EC 2.2.1.8     
Accepted name: fluorothreonine transaldolase
Reaction: L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine
Systematic name: fluoroacetaldehyde:L-threonine aldehydetransferase
Comments: A pyridoxal phosphate protein. Can also convert chloroacetaldehyde into4-chloro-L-threonine. Unlike EC 2.1.2.1, glycine hydroxymethyltransferase, does not use glycine as a substrate.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 403503-13-9
References:
1.  Murphy, C.D., O'Hagan, D. and Schaffrath, C. Identification of a PLP-dependent threonine transaldolase: a novel enzyme involved in 4-fluorothreonine biosynthesis in Streptomyces cattleya. Angew. Chem. Int. Ed. Engl. 40 (2001) 4479–4481. [PMID: 12404452]
2.  Murphy, C.D., Schaffrath, C. and O'Hagan, D. Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya. Chemosphere 52 (2003) 455–461. [PMID: 12738270]
[EC 2.2.1.8 created 2003]
 
 


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