The Enzyme Database

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EC 2.2.1.1     
Accepted name: transketolase
Reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate
For diagram of reaction, click here, for diagram of the calvin cycle, click here, for diagram of the calvin cycle, click here, for diagram of the calvin cycle, click here and for diagram of the pentose phosphate pathway (later stages), click here
Glossary: thiamine diphosphate
Other name(s): glycolaldehydetransferase
Systematic name: sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase
Comments: A thiamine-diphosphate protein. Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO2 and R-CHOH-CO-CH2OH. The enzyme from the bacterium Alcaligenes faecalis shows high activity with D-erythrose 4-phosphate as acceptor.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9014-48-6
References:
1.  De La Haba, G., Leder, I.G and Racker, E. Crystalline transketolase from bakers' yeast: isolation and properties. J. Biol. Chem. 214 (1955) 409–426. [PMID: 14367398]
2.  Domagk, G.F. and Horecker, B.L. Fructose and erythrose metabolism in Alcaligenes faecalis. Arch. Biochem. Biophys. 109 (1965) 342–349.
3.  Horecker, B.L., Smyrniotis, P.Z. and Hurwitz, J. The role of xylulose 5-phosphate in the transketolase reaction. J. Biol. Chem. 223 (1956) 1009–1019. [PMID: 13385248]
4.  Racker, E. Transketolase. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds), The Enzymes, 2nd edn, vol. 5, Academic Press, New York, 1961, pp. 397–412.
[EC 2.2.1.1 created 1961]
 
 


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