The Enzyme Database

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EC 2.2.1.1     
Accepted name: transketolase
Reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate
Glossary: thiamine diphosphate
Other name(s): glycolaldehydetransferase
Systematic name: sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase
Comments: A thiamine-diphosphate protein. Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO2 and R-CHOH-CO-CH2OH. Transketolase from Alkaligenes faecalis shows high activity with D-erythrose as acceptor.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9014-48-6
References:
1.  De La Haba, G., Leder, I.G and Racker, E. Crystalline transketolase from bakers' yeast: isolation and properties. J. Biol. Chem. 214 (1955) 409–426. [PMID: 14367398]
2.  Domagk, G.F. and Horecker, B.L. Fructose and erythrose metabolism in Alcaligenes faecalis. Arch. Biochem. Biophys. 109 (1965) 342–349.
3.  Horecker, B.L., Smyrniotis, P.Z. and Hurwitz, J. The role of xylulose 5-phosphate in the transketolase reaction. J. Biol. Chem. 223 (1956) 1009–1019. [PMID: 13385248]
4.  Racker, E. Transketolase. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds), The Enzymes, 2nd edn, vol. 5, Academic Press, New York, 1961, pp. 397–412.
[EC 2.2.1.1 created 1961]
 
 


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