The Enzyme Database

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Accepted name: methylated-DNA—[protein]-cysteine S-methyltransferase
Reaction: DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
Systematic name: DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase
Comments: This protein is involved in the repair of alkylated DNA. It acts only on the alkylated DNA (cf. EC, DNA-3-methyladenine glycosidase I and EC, DNA-3-methyladenine glycosidase II). This enzyme catalyses only one turnover and therefore is not strictly catalytic.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 77271-19-3
1.  Foote, R.S., Mitra, S. and Pal, B.C. Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichia coli. Biochem. Biophys. Res. Commun. 97 (1980) 654–659. [PMID: 7008792]
2.  Olsson, M. and Lindehl, T. Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue. J. Biol. Chem. 255 (1980) 10569–10571. [PMID: 7000780]
3.  Pegg, A.E. and Byers, T.L. Repair of DNA containing O6-alkylguanine. FASEB J. 6 (1992) 2302–2310. [PMID: 1544541]
[EC created 1982, modified 1983, modified 1999, modified 2003]

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