| EC |
2.1.1.63 |
| Accepted name: |
methylated-DNA—[protein]-cysteine S-methyltransferase |
| Reaction: |
DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine |
| Systematic name: |
DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase |
| Comments: |
This protein is involved in the repair of alkylated DNA. It acts only on the alkylated DNA (cf. EC 3.2.2.20, DNA-3-methyladenine glycosidase I and EC 3.2.2.21, DNA-3-methyladenine glycosidase II). This enzyme catalyses only one turnover and therefore is not strictly catalytic. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, METACYC, PDB, CAS registry number: 77271-19-3 |
| References: |
| 1. |
Foote, R.S., Mitra, S. and Pal, B.C. Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichia coli. Biochem. Biophys. Res. Commun. 97 (1980) 654–659. [PMID: 7008792] |
| 2. |
Olsson, M. and Lindehl, T. Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue. J. Biol. Chem. 255 (1980) 10569–10571. [PMID: 7000780] |
| 3. |
Pegg, A.E. and Byers, T.L. Repair of DNA containing O6-alkylguanine. FASEB J. 6 (1992) 2302–2310. [PMID: 1544541] |
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| [EC 2.1.1.63 created 1982, modified 1983, modified 1999, modified 2003] |
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