The Enzyme Database

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EC 2.1.1.339     
Accepted name: xanthohumol 4′-O-methyltransferase
Reaction: S-adenosyl-L-methionine + xanthohumol = S-adenosyl-L-homocysteine + 4′-O-methylxanthohumol
For diagram of xanthohumol biosynthesis, click here
Glossary: xanthohumol = 2′,4,4′-trihydroxy-6′-methoxy-3-prenylchalcone = (2E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
4′-O-methylxanthohumol =2′,4-dihydroxy-4′,6′-dimethoxy-3-prenylchalcone = (2E)-1-[2-hydroxy-4,6-dimethoxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
Other name(s): OMT2 (ambiguous)
Systematic name: S-adenosyl-L-methionine:xanthohumol 4′-O-methyltransferase
Comments: The enzyme from hops (Humulus lupulus) has a broad substrate specificity. The best substrates in vitro are resveratrol, desmethylxanthohumol, naringenin chalcone and isoliquiritigenin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Nagel, J., Culley, L.K., Lu, Y., Liu, E., Matthews, P.D., Stevens, J.F. and Page, J.E. EST analysis of hop glandular trichomes identifies an O-methyltransferase that catalyzes the biosynthesis of xanthohumol. Plant Cell 20 (2008) 186–200. [PMID: 18223037]
[EC 2.1.1.339 created 2017]
 
 


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