The Enzyme Database

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EC 2.1.1.338     
Accepted name: desmethylxanthohumol 6′-O-methyltransferase
Reaction: S-adenosyl-L-methionine + desmethylxanthohumol = S-adenosyl-L-homocysteine + xanthohumol
For diagram of xanthohumol biosynthesis, click here
Glossary: desmethylxanthohumol = 2′,4,4′,6′-tetrahydroxy-3-prenylchalcone = (2E)-3-(4-hydroxyphenyl)-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]prop-2-en-1-one
xanthohumol = 2′,4,4′-trihydroxy-6′-methoxy-3-prenylchalcone = (2E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
Other name(s): OMT1 (ambiguous)
Systematic name: S-adenosyl-L-methionine:desmethylxanthohumol 6′-O-methyltransferase
Comments: Found in hops (Humulus lupulus). The enzyme can also methylate xanthogalenol.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Nagel, J., Culley, L.K., Lu, Y., Liu, E., Matthews, P.D., Stevens, J.F. and Page, J.E. EST analysis of hop glandular trichomes identifies an O-methyltransferase that catalyzes the biosynthesis of xanthohumol. Plant Cell 20 (2008) 186–200. [PMID: 18223037]
[EC 2.1.1.338 created 2017]
 
 


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