| EC |
2.1.1.327 |
| Accepted name: |
phenazine-1-carboxylate N-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + phenazine-1-carboxylate = S-adenosyl-L-homocysteine + 5-methylphenazine-1-carboxylate |
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For diagram of enediyne antitumour antibiotic biosynthesis and pyocyanin biosynthesis, click here |
| Other name(s): |
phzM (gene name) |
| Systematic name: |
S-adenosyl-L-methionine:phenazine-1-carboxylate 5-methyltransferase |
| Comments: |
The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is involved in the biosynthesis of pyocyanin, a toxin produced and secreted by the organism. The enzyme is active in vitro only in the presence of EC 1.14.13.218, 5-methylphenazine-1-carboxylate 1-monooxygenase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Parsons, J.F., Greenhagen, B.T., Shi, K., Calabrese, K., Robinson, H. and Ladner, J.E. Structural and functional analysis of the pyocyanin biosynthetic protein PhzM from Pseudomonas aeruginosa. Biochemistry 46 (2007) 1821–1828. [DOI] [PMID: 17253782] |
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| [EC 2.1.1.327 created 2016] |
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