The Enzyme Database

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EC 2.1.1.308     
Accepted name: 2-hydroxyethylphosphonate methyltransferase
Reaction: S-adenosyl-L-methionine + methylcob(III)alamin + 2-hydroxyethylphosphonate = 5′-deoxyadenosine + L-methionine + cob(III)alamin + (2S)-2-hydroxypropylphosphonate
For diagram of fosfomycin biosynthesis, click here
Other name(s): Fom3
Systematic name: S-adenosyl-L-methionine:methylcob(III)alamin:2-hydroxyethylphosphonate methyltransferase
Comments: Requires cobalamin. The enzyme, isolated from the bacterium Streptomyces wedmorensis, is a member of the ‘AdoMet radical’ (radical SAM) family. Involved in fosfomycin biosynthesis.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Woodyer, R.D., Li, G., Zhao, H. and van der Donk, W.A. New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin. Chem. Commun. (Camb.) (2007) 359–361. [PMID: 17220970]
2.  Allen, K.D. and Wang, S.C. Initial characterization of Fom3 from Streptomyces wedmorensis: The methyltransferase in fosfomycin biosynthesis. Arch. Biochem. Biophys. 543 (2014) 67–73. [PMID: 24370735]
[EC 2.1.1.308 created 2014]
 
 


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