The Enzyme Database

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Accepted name: 2-hydroxyethylphosphonate methyltransferase
Reaction: S-adenosyl-L-methionine + methylcob(III)alamin + 2-hydroxyethylphosphonate = 5′-deoxyadenosine + L-methionine + cob(III)alamin + (2S)-2-hydroxypropylphosphonate
For diagram of fosfomycin biosynthesis, click here
Other name(s): Fom3
Systematic name: S-adenosyl-L-methionine:methylcob(III)alamin:2-hydroxyethylphosphonate methyltransferase
Comments: Requires cobalamin. The enzyme, isolated from the bacterium Streptomyces wedmorensis, is a member of the ‘AdoMet radical’ (radical SAM) family. Involved in fosfomycin biosynthesis.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Woodyer, R.D., Li, G., Zhao, H. and van der Donk, W.A. New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin. Chem. Commun. (Camb.) (2007) 359–361. [DOI] [PMID: 17220970]
2.  Allen, K.D. and Wang, S.C. Initial characterization of Fom3 from Streptomyces wedmorensis: The methyltransferase in fosfomycin biosynthesis. Arch. Biochem. Biophys. 543 (2014) 67–73. [DOI] [PMID: 24370735]
[EC created 2014]

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