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Accepted name: protein N-terminal monomethyltransferase
S-adenosyl- L-methionine + N-terminal-(A,P,S)PK-[protein] = S-adenosyl- L-homocysteine + N-terminal- N-methyl- N-(A,P,S)PK-[protein]
Other name(s): NRMT2 (
gene name); METTL11B ( gene name); N-terminal monomethylase
S-adenosyl- L-methionine:N-terminal-(A,P,S)PK-[protein] monomethyltransferase
Comments: This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator
L-methionine is cleaved. In contrast to EC 188.8.131.52, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal.
Links to other databases:
BRENDA, EXPASY, KEGG, MetaCyc
Petkowski, J.J., Bonsignore, L.A., Tooley, J.G., Wilkey, D.W., Merchant, M.L., Macara, I.G. and Schaner Tooley, C.E. NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1.
Biochem. J. 456 (2013) 453–462. [ DOI] [PMID: 24090352]
[EC 184.108.40.2069 created 2014]
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