The Enzyme Database

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EC 2.1.1.28     
Accepted name: phenylethanolamine N-methyltransferase
Reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine
For diagram of dopa biosynthesis, click here
Other name(s): noradrenaline N-methyltransferase; noradrenalin N-methyltransferase; norepinephrine methyltransferase; norepinephrine N-methyltransferase; phenethanolamine methyltransferase; phenethanolamine N-methyltransferase
Systematic name: S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase
Comments: Acts on various phenylethanolamines; converts noradrenaline into adrenaline.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9037-68-7
References:
1.  Axelrod, J. Purification and properties of phenylethanolamine-N-methyl transferase. J. Biol. Chem. 237 (1962) 1657–1660. [PMID: 13863458]
2.  Connett, R.J. and Kirschner, N. Purification and properties of bovine phenylethanolamine N-methyltransferase. J. Biol. Chem. 245 (1970) 329–334. [PMID: 5412063]
[EC 2.1.1.28 created 1972]
 
 


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