The Enzyme Database

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Accepted name: 16S rRNA (cytidine1409-2′-O)-methyltransferase
Reaction: S-adenosyl-L-methionine + cytidine1409 in 16S rRNA = S-adenosyl-L-homocysteine + 2′-O-methylcytidine1409 in 16S rRNA
Other name(s): TlyA (ambiguous)
Systematic name: S-adenosyl-L-methionine:16S rRNA (cytidine1409-2′-O)-methyltransferase
Comments: The bifunctional enzyme from Mycobacterium tuberculosis 2′-O-methylates cytidine1409 in helix 44 of 16S rRNA and cytidine1920 in helix 69 of 23S rRNA (cf. EC, 23S rRNA (cytidine1920-2′-O)-methyltransferase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Johansen, S.K., Maus, C.E., Plikaytis, B.B. and Douthwaite, S. Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2′-O-methylations in 16S and 23S rRNAs. Mol. Cell 23 (2006) 173–182. [PMID: 16857584]
2.  Maus, C.E., Plikaytis, B.B. and Shinnick, T.M. Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 49 (2005) 571–577. [PMID: 15673735]
[EC created 2011]

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