ExplorEnz: EC 2.1.1.225

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2.1.1.225

Accepted name:

tRNA:m⁴X modification enzyme

Reaction:

(1) S-adenosyl-L-methionine + cytidine⁴ in tRNA^Pro = S-adenosyl-L-homocysteine + 2′-O-methylcytidine⁴ in tRNA^Pro
(2) S-adenosyl-L-methionine + cytidine⁴ in tRNA^Gly(GCC) = S-adenosyl-L-homocysteine + 2′-O-methylcytidine⁴ in tRNA^Gly(GCC)
(3) S-adenosyl-L-methionine + adenosine⁴ in tRNA^His = S-adenosyl-L-homocysteine + 2′-O-methyladenosine⁴ in tRNA^His

For diagram of bornane and related monoterpenoids, click here

Other name(s):

TRM13; Trm13p; tRNA:Xm4 modification enzyme

Systematic name:

S-adenosyl-L-methionine:tRNA^Pro/His/Gly(GCC) (cytidine/adenosine⁴-2′-O)-methyltransferase

Comments:

The enzyme from Saccharomyces cerevisiae 2′-O-methylates cytidine⁴ in tRNA^Pro and tRNA^Gly(GCC), and adenosine⁴ in tRNA^His.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Wilkinson, M.L., Crary, S.M., Jackman, J.E., Grayhack, E.J. and Phizicky, E.M. The 2′-O-methyltransferase responsible for modification of yeast tRNA at position 4. RNA 13 (2007) 404–413. [DOI] [PMID: 17242307]

[EC 2.1.1.225 created 2011]