| EC |
2.1.1.185 |
| Accepted name: |
23S rRNA (guanosine2251-2′-O)-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + guanosine2251 in 23S rRNA = S-adenosyl-L-homocysteine + 2′-O-methylguanosine2251 in 23S rRNA |
| Other name(s): |
rlmB (gene name); yifH (gene name) |
| Systematic name: |
S-adenosyl-L-methionine:23S rRNA (guanosine2251-2′-O-)-methyltransferase |
| Comments: |
The enzyme catalyses the methylation of guanosine2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Lovgren, J.M. and Wikstrom, P.M. The rlmB gene is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli. J. Bacteriol. 183 (2001) 6957–6960. [DOI] [PMID: 11698387] |
| 2. |
Michel, G., Sauve, V., Larocque, R., Li, Y., Matte, A. and Cygler, M. The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot. Structure 10 (2002) 1303–1315. [DOI] [PMID: 12377117] |
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| [EC 2.1.1.185 created 2010] |
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