ExplorEnz: EC 2.1.1.176

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2.1.1.176

Accepted name:

16S rRNA (cytosine⁹⁶⁷-C⁵)-methyltransferase

Reaction:

S-adenosyl-L-methionine + cytosine⁹⁶⁷ in 16S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine⁹⁶⁷ in 16S rRNA

Other name(s):

rsmB (gene name); fmu (gene name); 16S rRNA m⁵C⁹⁶⁷ methyltransferase

Systematic name:

S-adenosyl-L-methionine:16S rRNA (cytosine⁹⁶⁷-C⁵)-methyltransferase

Comments:

The enzyme specifically methylates cytosine⁹⁶⁷ at C⁵ in 16S rRNA.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Tscherne, J.S., Nurse, K., Popienick, P., Michel, H., Sochacki, M. and Ofengand, J. Purification, cloning, and characterization of the 16S RNA m⁵C⁹⁶⁷ methyltransferase from Escherichia coli. Biochemistry 38 (1999) 1884–1892. [DOI] [PMID: 10026269]
2.	Gu, X.R., Gustafsson, C., Ku, J., Yu, M. and Santi, D.V. Identification of the 16S rRNA m⁵C⁹⁶⁷ methyltransferase from Escherichia coli. Biochemistry 38 (1999) 4053–4057. [DOI] [PMID: 10194318]
3.	Foster, P.G., Nunes, C.R., Greene, P., Moustakas, D. and Stroud, R.M. The first structure of an RNA m⁵C methyltransferase, Fmu, provides insight into catalytic mechanism and specific binding of RNA substrate. Structure 11 (2003) 1609–1620. [DOI] [PMID: 14656444]

[EC 2.1.1.176 created 2010]